Is human agency Noah's big unchallenged assumption?

For me, it's hard not to read this (from Noah Smith):
But the real reason you have this tradeoff is because you have big huge unchallenged assumptions in the background governing your entire model-making process. By focusing on norms you ignore production costs, consumption utility, etc. You can tinker with the silly curve-fitting assumptions in the macro model all you like, but it won't do you any good, because you're using the wrong kind of model in the first place.
So when we see this kind of tradeoff popping up a lot, I think it's a sign that there are some big deep problems with the modeling framework. [Emphasis in original]
And think of this (from me):
Do we really know [that macroeconomics is the result of a whole bunch of little economic decisions by individuals and companies]? For a fact? To be specific, I'm not questioning the idea that an economy is made up of humans making decisions with money (of course it is) -- I'm questioning the idea that observed macroeconomic relationships (price level and money supply, RGDP and employment) are the result of humans making decisions with money.
There's a lot more on that front in the information transfer framework: utility maximization, Euler equations, price stickiness ... even money itself. It is possible that our decisions have only a limited impact most of the time. And when our decisions matter, it's mostly for the worse.